If your child is under the age of 2, ask your doctor for the correct dose. Tylenol 8 HR Arthritis Pain (Extended Release)įor children, the dose varies according to weight. Those who survive an acetaminophen overdose without needing a liver transplant may experience long-term liver damage.
Among those who have liver failure, 29 percent require a liver transplant. This triggers a chain of reactions that can lead to death.Īccording to a 2016 literature review, liver failure caused by acetaminophen overdose causes death in approximately 28 percent of cases. In severe cases, it can cause liver failure. In the liver, it kills cells and causes irreversible tissue damage. Taking too much Tylenol changes the way it’s metabolized in your liver, resulting in an increase in a metabolite (a by-product of metabolism) called N-acetyl-p-benzoquinone imine (NAPQI). Eventually, it’s broken down (metabolized) in your liver and excreted in your urine. It starts to take effect in 45 minutes for most oral forms, or up to 2 hours for suppositories. When you take a normal dose, it enters your gastrointestinal tract and is absorbed into your bloodstream. This can happen if you take more than the recommended dosage. It’s possible to overdose on acetaminophen.
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